EXPERIENCE OF DEPARTMENT OF ONCOLOGY AND RADIOTHERAPY IN THREEDIMENSIONAL CONFORMAL CHEMORADIOTHERAPY OF NON-SMALL CELL LUNG CANCER - DOSIMETRIC STUDY

Abstract

Aim of the study: To investigate organs-at-risk toxicity with concomitant chemo radiotherapy in non-small cell lung cancer
patients, and to explore dosimetry trends for organs-at-risk over the years. To investigate the rates of acute toxicities and to compare the results with the worldwide literature.
Subjects and methods: This is a retrospective study conducted at the Department of Oncology and Radiotherapy at University Hospital of Split. Data were collected from patients with locally advanced non-small cell lung cancer treated with three-dimensional conformal chemo radiotherapy from 2011 to early 2019. Data were collected from patients who were treated with primary, adjuvant, and/or neoadjuvant radiotherapy. The patients received at least one cycle of chemotherapy. The target volumes and organs of
risk were delineated according to radiotherapy guidelines.
Results: The median dose on planning treatment volume was 56 Gy. The most common acute radiation toxicity was radiation esophagitis. No cases of acute radiation pneumonitis were noted. No correlation has been noted between dose override on organsat- risk volumes and toxicity, and we have shown a trend of improved dosimetry results through the years.
Conclusion: The toxicity of treatment with 3D conformal radiotherapy for locally advanced lung cancer at the Department of Oncology and Radiotherapy at University Hospital of Split is comparable to the published results of other worldwide institutions. With longer use of 3D conformal radiotherapy we have seen improved dosimetry results over the years.